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KMID : 1161420170200020124
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Journal of Medicinal Food
2017 Volume.20 No. 2 p.124 ~ p.130
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Capsicum annuum var. grossum (Bell Pepper) Inhibits β-Secretase Activity and β-Amyloid1?40 Aggregation
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Ogunruku Omodesola Oluwafisayo
Oboh Ganiyu
Passamonti Sabina
Tramer Federica
Boligon Aline Augusti
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Abstract
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The deposition of amyloid protein as senile plaques is the major signature of Alzheimer's disease (AD). It is produced by the sequential cleavage of the amyloid precursor protein by secretases. Moreover, peppers are noted for their antiaging and cognitive enhancing properties. Thus, in this study, the effects of polyphenol-rich extracts from bell pepper on amyloid production and aggregation in vitro were investigated. Bell pepper (ripe and unripe) was extracted with methanol-1?N HCl (1:1?v/v). Thereafter, the inhibitory potentials of the extracts on β-secretase and β-amyloid1?40 aggregation were determined. Phenolic composition of the pepper fruits was further determined by HPLC-DAD (high performance liquid chromatography?diode array detector). There was a dose-dependent inhibition of β-secretase by the pepper fruits with the ripe fruits (2.17?±?0.17?μg/L) showing a significantly (P?
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KEYWORD
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β-amyloid1?40, β-secretase, Alzheimer's disease, neurodegeneration, bell pepper, Capsicum spp
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